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Mitochondrial DNA mutations and aging: devils in the details?
Although several lines of evidence support a role for accumulating somatic mitochondrial DNA (mtDNA) mutations in the etiology of aging, it remains unclear if they are a major cause of age-related deterioration and death. Mouse models that harbor elevated mtDNA mutation frequencies age prematurely;...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811092/ https://ncbi.nlm.nih.gov/pubmed/19110336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2008.11.007 |
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