Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

Dysregulated glutamatergic neurotransmission has been strongly implicated in the pathophysiology of schizophrenia (SCZ). Recently, presynaptic modulation of glutamate transmission has been shown to have therapeutic promise. We asked whether genetic knockdown of glutaminase (gene GLS1) to reduce glut...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gaisler-Salomon, Inna, Miller, Gretchen M, Chuhma, Nao, Lee, Sooyeon, Zhang, Hong, Ghoddoussi, Farhad, Lewandowski, Nicole, Fairhurst, Stephen, Wang, Yvonne, Conjard-Duplany, Agnès, Masson, Justine, Balsam, Peter, Hen, René, Arancio, Ottavio, Galloway, Matthew P, Moore, Holly M, Small, Scott A, Rayport, Stephen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811085/
https://ncbi.nlm.nih.gov/pubmed/19516252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.58
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