Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice

Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands. Here for the first time, we have implemented this strategy to address the potential therapeutic value of a glutamate-based pharmacot...

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Detalhes bibliográficos
Publicado no:Front Syst Neurosci
Main Authors: Mingote, Susana, Masson, Justine, Gellman, Celia, Thomsen, Gretchen M., Lin, Chyuan-Sheng, Merker, Robert J., Gaisler-Salomon, Inna, Wang, Yvonne, Ernst, Rachel, Hen, René, Rayport, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705219/
https://ncbi.nlm.nih.gov/pubmed/26778975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsys.2015.00165
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