Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

Dysregulated glutamatergic neurotransmission has been strongly implicated in the pathophysiology of schizophrenia (SCZ). Recently, presynaptic modulation of glutamate transmission has been shown to have therapeutic promise. We asked whether genetic knockdown of glutaminase (gene GLS1) to reduce glut...

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Main Authors: Gaisler-Salomon, Inna, Miller, Gretchen M, Chuhma, Nao, Lee, Sooyeon, Zhang, Hong, Ghoddoussi, Farhad, Lewandowski, Nicole, Fairhurst, Stephen, Wang, Yvonne, Conjard-Duplany, Agnès, Masson, Justine, Balsam, Peter, Hen, René, Arancio, Ottavio, Galloway, Matthew P, Moore, Holly M, Small, Scott A, Rayport, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811085/
https://ncbi.nlm.nih.gov/pubmed/19516252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.58
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