Mice Lacking Brain/Kidney Phosphate-Activated Glutaminase Have Impaired Glutamatergic Synaptic Transmission, Altered Breathing, Disorganized Goal-Directed Behavior and Die Shortly after Birth

Neurotransmitter glutamate has been thought to derive mainly from glutamine via the action of glutaminase type 1 (GLS1). To address the importance of this pathway in glutamatergic transmission, we knocked out GLS1 in mice. The insertion of a STOP cassette by homologous recombination produced a null...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Masson, Justine, Darmon, Michèle, Conjard, Agnès, Chuhma, Nao, Ropert, Nicole, Thoby-Brisson, Muriel, Foutz, Arthur S., Parrot, Sandrine, Miller, Gretchen M., Jorisch, Renée, Polan, Jonathan, Hamon, Michel, Hen, René, Rayport, Stephen
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Society for Neuroscience 2006
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Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745954/
https://ncbi.nlm.nih.gov/pubmed/16641247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4241-05.2006
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