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Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples

Genomic technologies, such as array comparative genomic hybridization (aCGH), increasingly offer definitive gene dosage profiles in clinical samples. Historically, copy number profiling was limited to large fresh-frozen tumors where intact DNA could be readily extracted. Genomic analyses of pre-neop...

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Bibliographische Detailangaben
Hauptverfasser: Hostetter, Galen, Kim, Su Young, Savage, Stephanie, Gooden, Gerald C., Barrett, Michael, Zhang, Jian, Alla, Lalitamba, Watanabe, April, Einspahr, Janine, Prasad, Anil, Nickoloff, Brian J., Carpten, John, Trent, Jeffrey, Alberts, David, Bittner, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811007/
https://ncbi.nlm.nih.gov/pubmed/19875416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp881
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