Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers

Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Recent structural studies have shown that neurotrophins interact with dimers of the p75 neurotrophin receptor (p75(NTR)), but the actual mechanism of receptor activation has remained elusive. Here...

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Auteurs principaux: Vilar, Marçal, Charalampopoulos, Ioannis, Kenchappa, Rajappa S., Simi, Anastasia, Karaca, Esra, Reversi, Alessandra, Choi, Soyoung, Bothwell, Mark, Mingarro, Ismael, Friedman, Wilma J., Schiavo, Giampietro, Bastiaens, Philippe I. H., Verveer, Peter J., Carter, Bruce D., Ibáñez, Carlos F.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810632/
https://ncbi.nlm.nih.gov/pubmed/19376068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.02.020
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