Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers

Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Recent structural studies have shown that neurotrophins interact with dimers of the p75 neurotrophin receptor (p75(NTR)), but the actual mechanism of receptor activation has remained elusive. Here...

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Detalhes bibliográficos
Main Authors: Vilar, Marçal, Charalampopoulos, Ioannis, Kenchappa, Rajappa S., Simi, Anastasia, Karaca, Esra, Reversi, Alessandra, Choi, Soyoung, Bothwell, Mark, Mingarro, Ismael, Friedman, Wilma J., Schiavo, Giampietro, Bastiaens, Philippe I. H., Verveer, Peter J., Carter, Bruce D., Ibáñez, Carlos F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810632/
https://ncbi.nlm.nih.gov/pubmed/19376068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.02.020
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