Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

Dimerization is recognized as a crucial step in the activation of many plasma membrane receptors. However, a growing number of receptors pre-exist as dimers in the absence of ligand, indicating that, although necessary, dimerization is not always sufficient for signaling. The p75 neurotrophin recept...

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Bibliografiske detaljer
Main Authors: Vilar, Marçal, Charalampopoulos, Ioannis, Kenchappa, Rajappa S., Reversi, Alessandra, Klos-Applequist, Joanna M., Karaca, Esra, Simi, Anastasia, Spuch, Carlos, Choi, Soyoung, Friedman, Wilma J., Ericson, Johan, Schiavo, Giampietro, Carter, Bruce D., Ibáñez, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736866/
https://ncbi.nlm.nih.gov/pubmed/19706676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.055061
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