An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.

Most Borrelia burgdorferi strains have two major surface proteins, OspA and OspB. In the present study, we selected from a clonal population of infectious B. burgdorferi an OspB escape mutant, identified the genetic basis for this phenotype, and evaluated its functional activities. Selection with th...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Sadziene, A, Barbour, A G, Rosa, P A, Thomas, D D
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281052/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8359881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.9.3590-3596.1993
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