An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.

Most Borrelia burgdorferi strains have two major surface proteins, OspA and OspB. In the present study, we selected from a clonal population of infectious B. burgdorferi an OspB escape mutant, identified the genetic basis for this phenotype, and evaluated its functional activities. Selection with th...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Sadziene, A, Barbour, A G, Rosa, P A, Thomas, D D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281052/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8359881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.9.3590-3596.1993
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