Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular trafficking, and effects. We studied this using pro...

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Autores principales: Muro, Silvia, Garnacho, Carmen, Champion, Julie A, Leferovich, John, Gajewski, Christine, Schuchman, Edward H, Mitragotri, Samir, Muzykantov, Vladimir R
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810502/
https://ncbi.nlm.nih.gov/pubmed/18560419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.127
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