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Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor
Oligomerization of human Islet Amyloid Polypeptide (IAPP) has been increasingly considered a primary pathogenic process in Type II Diabetes. Here structural features of the IAPP monomer have been probed using a combination of Ion Mobility Mass Spectrometry (IMS-MS) and all-atom Replica Exchange Mole...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810149/ https://ncbi.nlm.nih.gov/pubmed/19950949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903814q |
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