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The Amyloid Formation Mechanism in Human IAPP: Dimers have β-strand Monomer-Monomer Interfaces
Early oligomerization of human IAPP (hIAPP) is responsible for β-cell death in the pancreas and is increasingly considered a primary pathological process linked to Type II Diabetes (T2D). However, the assembly mechanism remains poorly understood, largely due to the inability of conventional techniqu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093713/ https://ncbi.nlm.nih.gov/pubmed/21517093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1081537 |
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