Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

Oligomerization of human Islet Amyloid Polypeptide (IAPP) has been increasingly considered a primary pathogenic process in Type II Diabetes. Here structural features of the IAPP monomer have been probed using a combination of Ion Mobility Mass Spectrometry (IMS-MS) and all-atom Replica Exchange Mole...

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Hlavní autoři: Dupuis, Nicholas F., Wu, Chun, Shea, Joan-Emma, Bowers, Michael T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810149/
https://ncbi.nlm.nih.gov/pubmed/19950949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903814q
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