INTRARENAL AMINOPEPTIDASE N INHIBITION RESTORES DEFECTIVE AT(2)R-MEDIATED NATRIURESIS IN SHR

The preferred ligand of AT(2)R-mediated natriuresis is Ang III. The major enzyme responsible for the metabolism of Ang III is aminopeptidase N (APN), which is selectively inhibited by compound PC-18. In this study, urine sodium excretion rates (U(Na)V), fractional excretion of sodium (FE(Na)) and li...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Padia, Shetal H., Howell, Nancy L., Kemp, Brandon A., Fournie-Zaluski, Marie-Claude, Roques, Bernard P., Carey, Robert M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809800/
https://ncbi.nlm.nih.gov/pubmed/19996063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.144956
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