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INTRARENAL AMINOPEPTIDASE N INHIBITION RESTORES DEFECTIVE AT(2)R-MEDIATED NATRIURESIS IN SHR
The preferred ligand of AT(2)R-mediated natriuresis is Ang III. The major enzyme responsible for the metabolism of Ang III is aminopeptidase N (APN), which is selectively inhibited by compound PC-18. In this study, urine sodium excretion rates (U(Na)V), fractional excretion of sodium (FE(Na)) and li...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2809800/ https://ncbi.nlm.nih.gov/pubmed/19996063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.144956 |
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