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At(2) Receptor Activation Induces Natriuresis and Lowers Blood Pressure

RATIONALE: Compound 21 (C-21) is a highly selective non-peptide AT(2) receptor (AT(2)R) agonist. OBJECTIVE: To test the hypothesis that renal proximal tubule AT(2)Rs induce natriuresis and lower blood pressure (BP) in Sprague-Dawley rats and mice. METHODS AND RESULTS: In rats, AT(2)R activation with...

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Détails bibliographiques
Auteurs principaux: Kemp, Brandon A., Howell, Nancy L., Gildea, John J., Keller, Susanna R., Padia, Shetal H., Carey, Robert M.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116673/
https://ncbi.nlm.nih.gov/pubmed/24903104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.304110
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