BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

BRIT1 protein (also known as MCPH1) contains 3 BRCT domains which are conserved in BRCA1, BRCA2, and other important molecules involved in DNA damage signaling, DNA repair, and tumor suppression. BRIT1 mutations or aberrant expression are found in primary microcephaly patients as well as in cancer p...

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Main Authors: Liang, Yulong, Gao, Hong, Lin, Shiaw-Yih, Peng, Guang, Huang, Xingxu, Zhang, Pumin, Goss, John A., Brunicardi, Francis C., Multani, Asha S., Chang, Sandy, Li, Kaiyi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809772/
https://ncbi.nlm.nih.gov/pubmed/20107607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000826
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