DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

OBJECTIVES: The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological differences from the human respiratory tract in vivo. Here we report the pharmacodynamics of DAS181, a sialidase fusion protein that inhibits...

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Hauptverfasser: Triana-Baltzer, Gallen B., Babizki, Maria, Chan, Michael C. W., Wong, Adam C. N., Aschenbrenner, Laura M., Campbell, Erin R., Li, Qi-Xiang, Chan, Renee W. Y., Peiris, J. S. Malik, Nicholls, John M., Fang, Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809246/
https://ncbi.nlm.nih.gov/pubmed/19942616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp421
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