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INO-4995 Therapeutic Efficacy Is Enhanced with Repeat Dosing in Cystic Fibrosis Knockout Mice and Human Epithelia

Progressive lung damage in cystic fibrosis (CF) has been linked to inadequate airway mucosal hydration. We previously demonstrated that an inositol tetrakisphosphate analog, 1-O-octyl-2-O-butyryl-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester (INO-4995), regulates airway secre...

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Detalhes bibliográficos
Main Authors: Traynor-Kaplan, Alexis E., Moody, Mark, Nur, Magda, Gabriel, Sherif, Majerus, Philip W., Drumm, Mitchell L., Langton-Webster, Beatrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809217/
https://ncbi.nlm.nih.gov/pubmed/19346319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0380OC
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