INO-4995 Therapeutic Efficacy Is Enhanced with Repeat Dosing in Cystic Fibrosis Knockout Mice and Human Epithelia

Progressive lung damage in cystic fibrosis (CF) has been linked to inadequate airway mucosal hydration. We previously demonstrated that an inositol tetrakisphosphate analog, 1-O-octyl-2-O-butyryl-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester (INO-4995), regulates airway secre...

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Main Authors: Traynor-Kaplan, Alexis E., Moody, Mark, Nur, Magda, Gabriel, Sherif, Majerus, Philip W., Drumm, Mitchell L., Langton-Webster, Beatrice
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809217/
https://ncbi.nlm.nih.gov/pubmed/19346319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0380OC
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