INO-4995 Therapeutic Efficacy Is Enhanced with Repeat Dosing in Cystic Fibrosis Knockout Mice and Human Epithelia

Progressive lung damage in cystic fibrosis (CF) has been linked to inadequate airway mucosal hydration. We previously demonstrated that an inositol tetrakisphosphate analog, 1-O-octyl-2-O-butyryl-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester (INO-4995), regulates airway secre...

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Hauptverfasser: Traynor-Kaplan, Alexis E., Moody, Mark, Nur, Magda, Gabriel, Sherif, Majerus, Philip W., Drumm, Mitchell L., Langton-Webster, Beatrice
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809217/
https://ncbi.nlm.nih.gov/pubmed/19346319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0380OC
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