Inositol polyphosphate derivative inhibits Na(+) transport and improves fluid dynamics in cystic fibrosis airway epithelia

Amiloride-sensitive, epithelial Na(+) channel (ENaC)-mediated, active absorption of Na(+) is elevated in the airway epithelium of cystic fibrosis (CF) patients, resulting in excess fluid removal from the airway lumen. This excess fluid/volume absorption corresponds to CF transmembrane regulator-link...

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Hlavní autoři: Moody, Mark, Pennington, Carey, Schultz, Carsten, Caldwell, Ray, Dinkel, Carlo, Rossi, Michael W., McNamara, Sharon, Widdicombe, Jonathan, Gabriel, Sherif, Traynor-Kaplan, Alexis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800890/
https://ncbi.nlm.nih.gov/pubmed/15857902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00591.2004
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