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In AβPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AβPP751 and GSK3β activation; effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis
Muscle fiber degeneration in sporadic inclusion-body myositis (s-IBM) is characterized by accumulation of multiprotein aggregates, including aggregated amyloid-β-precursor protein 751 (AβPP(751)), amyloid-β (Aβ), phosphorylated tau (p-tau), and other “Alzheimer-characteristic” proteins. Proteasome i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2809129/ https://ncbi.nlm.nih.gov/pubmed/19878439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06461.x |
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