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AβPP overexpression and proteasome inhibition increase αB-crystallin in cultured human muscle: relevance to inclusion-body myositis.
Amyloid-β precursor protein (AβPP) and its fragment amyloid-β (Aβ) are increased in s-IBM muscle fibers and appear to play an important role in the pathogenic cascade. αB-crystallin (αBC) was shown immunohistochemically to be accumulated in s-IBM muscle fibers, but the stressor(s) influencing αBC ac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976411/ https://ncbi.nlm.nih.gov/pubmed/17056255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nmd.2006.08.009 |
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