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PH-dependent Conformational Changes in Tear Lipocalin by Site Directed Tryptophan Fluorescence

Tear lipocalin (TL), a major protein of human tears, binds a broad array of endogenous ligands. PH-dependent ligand binding in TL may have functional implications in tears. Previously, conformational selections of the loops AB and GH have been implicated in ligand binding by site-directed tryptophan...

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Autors principals: Gasymov, Oktay K., Abduragimov, Adil R., Glasgow, Ben J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808433/
https://ncbi.nlm.nih.gov/pubmed/20025287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901435q
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