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Differences of globin transgene expression in stably transfected cell lines and transgenic mice

Previous studies demonstrated that DNase I hypersensitive site −40 (HS-40) of the α-globin locus is capable of greatly enhancing expression of a hybrid β/γ-globin transcriptional unit in plasmid-transfected murine erythroleukemia (MEL) cells. However, as reported here, this same γ-globin gene expres...

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Bibliografische gegevens
Hoofdauteurs: Li, Qiliang, Emery, David W., Han, Hemei, Sun, Jin, Yu, Man, Stamatoyannopoulos, George
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808413/
https://ncbi.nlm.nih.gov/pubmed/15626741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-03-0987
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