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Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes
High-level β-globin gene expression is dependent on the presence of the locus control region (LCR), a powerful regulatory element physically characterized by five DNase I-hypersensitive sites (HS), designated HS1–HS5. Of these, HS3 contains seven GT motifs that are essential for its activity. One of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808411/ https://ncbi.nlm.nih.gov/pubmed/14506128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddg319 |
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