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Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs
[Image: see text] GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bi-functionalize these PROLI/NO prodrugs, which on activation generate up to 4 moles of NO, a peptide residue and an N-acety...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808138/ https://ncbi.nlm.nih.gov/pubmed/19954198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol902481s |
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