Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis

Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mous...

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Bibliografski detalji
Glavni autori: Dongiovanni, Paola, Fracanzani, Anna Ludovica, Cairo, Gaetano, Megazzini, Chiara Paola, Gatti, Stefano, Rametta, Raffaela, Fargion, Silvia, Valenti, Luca
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2010
Teme:
Regular Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808103/
https://ncbi.nlm.nih.gov/pubmed/20019189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090249
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