Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis

Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mous...

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Hlavní autoři: Dongiovanni, Paola, Fracanzani, Anna Ludovica, Cairo, Gaetano, Megazzini, Chiara Paola, Gatti, Stefano, Rametta, Raffaela, Fargion, Silvia, Valenti, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808103/
https://ncbi.nlm.nih.gov/pubmed/20019189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090249
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