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Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis
Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mous...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Investigative Pathology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808103/ https://ncbi.nlm.nih.gov/pubmed/20019189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090249 |
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