Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis

Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mous...

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Bibliografiske detaljer
Main Authors: Dongiovanni, Paola, Fracanzani, Anna Ludovica, Cairo, Gaetano, Megazzini, Chiara Paola, Gatti, Stefano, Rametta, Raffaela, Fargion, Silvia, Valenti, Luca
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808103/
https://ncbi.nlm.nih.gov/pubmed/20019189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090249
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