Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis

Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mous...

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Detalhes bibliográficos
Main Authors: Dongiovanni, Paola, Fracanzani, Anna Ludovica, Cairo, Gaetano, Megazzini, Chiara Paola, Gatti, Stefano, Rametta, Raffaela, Fargion, Silvia, Valenti, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808103/
https://ncbi.nlm.nih.gov/pubmed/20019189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090249
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