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Iron Depletion by Deferoxamine Up-Regulates Glucose Uptake and Insulin Signaling in Hepatoma Cells and in Rat Liver

Iron depletion improves insulin resistance in patients with nonalcoholic fatty liver disease and diabetes and also stabilizes the hypoxia-inducible factor (HIF)-1, resulting in increased glucose uptake in vitro. This study investigated the effect of iron depletion by deferoxamine on insulin signalin...

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Detalhes bibliográficos
Main Authors: Dongiovanni, Paola, Valenti, Luca, Ludovica Fracanzani, Anna, Gatti, Stefano, Cairo, Gaetano, Fargion, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258266/
https://ncbi.nlm.nih.gov/pubmed/18245813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070097
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