CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

Successful neonatal immunization of humans has proven difficult. We have evaluated CpG-containing oligonucleotides as an adjuvant for immunization of young mice (1–14 days old) against hepatitis B virus surface antigen. The protein-alum-CpG formulation, like the DNA vaccine, produced seroconversion...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Millan, Cynthia L. Brazolot, Weeratna, Risini, Krieg, Arthur M., Siegrist, Claire-Anne, Davis, Heather L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9861007/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15553
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