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Single-stranded DNA oligonucleotides containing CpG motifs are non-stimulatory in vitro but offer protection in vivo against Burkholderia pseudomallei

Therapies that modulate and appropriately direct the immune response are promising candidates for the treatment of infectious diseases. One such candidate therapeutic is DZ13, a short, synthetic, single-stranded DNA molecule. This molecule has enzymatic activity and can modulate the immune response...

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Principais autores: Andrew Scott, Benjamin Farrar, Tom Young, Joann Prior, Chad Stratilo, Leonie Unterholzner, Riccardo D’Elia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-10-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
melioidosis
DNAzyme
CpG
anti-inflammatory
Burkholderia pseudomallei
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1458435/full
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