Single-stranded DNA oligonucleotides containing CpG motifs are non-stimulatory in vitro but offer protection in vivo against Burkholderia pseudomallei

Therapies that modulate and appropriately direct the immune response are promising candidates for the treatment of infectious diseases. One such candidate therapeutic is DZ13, a short, synthetic, single-stranded DNA molecule. This molecule has enzymatic activity and can modulate the immune response...

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Главные авторы:	Andrew Scott, Benjamin Farrar, Tom Young, Joann Prior, Chad Stratilo, Leonie Unterholzner, Riccardo D’Elia
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2024-10-01
Серии:	Frontiers in Cellular and Infection Microbiology
Предметы:	melioidosis DNAzyme CpG anti-inflammatory Burkholderia pseudomallei
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fcimb.2024.1458435/full
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