CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

Successful neonatal immunization of humans has proven difficult. We have evaluated CpG-containing oligonucleotides as an adjuvant for immunization of young mice (1–14 days old) against hepatitis B virus surface antigen. The protein-alum-CpG formulation, like the DNA vaccine, produced seroconversion...

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Bibliographische Detailangaben
Hauptverfasser: Millan, Cynthia L. Brazolot, Weeratna, Risini, Krieg, Arthur M., Siegrist, Claire-Anne, Davis, Heather L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC28081/
https://ncbi.nlm.nih.gov/pubmed/9861007
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