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Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice

In transgenic mice overexpressing the major myelin protein of the central nervous system, proteolipid protein, CD8+ T-lymphocytes mediate the primarily genetically caused myelin and axon damage. In the present study, we investigated the cellular and molecular mechanisms underlying this immune-relate...

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書誌詳細
主要な著者: Kroner, Antje, Ip, Chi Wang, Thalhammer, Johannes, Nave, Klaus-Armin, Martini, Rudolf
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Investigative Pathology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808063/
https://ncbi.nlm.nih.gov/pubmed/20042681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090722
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