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Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice
In transgenic mice overexpressing the major myelin protein of the central nervous system, proteolipid protein, CD8+ T-lymphocytes mediate the primarily genetically caused myelin and axon damage. In the present study, we investigated the cellular and molecular mechanisms underlying this immune-relate...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808063/ https://ncbi.nlm.nih.gov/pubmed/20042681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090722 |
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