Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse

Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport. Using fluorogold stereotactically injected into the colliculus superior, we found that PLP...

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Main Authors: Ip, Chi Wang, Kroner, Antje, Groh, Janos, Huber, Marianne, Klein, Dennis, Spahn, Irene, Diem, Ricarda, Williams, Sarah K., Nave, Klaus-Armin, Edgar, Julia M., Martini, Rudolf
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414455/
https://ncbi.nlm.nih.gov/pubmed/22905147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042554
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