Immune Cells Contribute to Myelin Degeneration and Axonopathic Changes in Mice Overexpressing Proteolipid Protein in Oligodendrocytes

Overexpression of the major myelin protein of the CNS, proteolipid protein (PLP), leads to late-onset degeneration of myelin and pathological changes in axons. Based on the observation that in white matter tracts of these mutants both CD8+ T-lymphocytes and CD11b+ macrophage-like cells are numerical...

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Published in:J Neurosci
Main Authors: Ip, Chi Wang, Kroner, Antje, Bendszus, Martin, Leder, Christoph, Kobsar, Igor, Fischer, Stefan, Wiendl, Heinz, Nave, Klaus-Armin, Martini, Rudolf
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673777/
https://ncbi.nlm.nih.gov/pubmed/16885234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1921-06.2006
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