Chiral spiroaminoborate ester as a highly enantioselective and efficient catalyst for the borane reduction of furyl, thiophene, chroman and thiochroman containing ketones

Prochiral heteroaryl ketones containing furan, thiophene, chroman and thiochroman moieties were successfully reduced in the presence of 1 – 10 mol % of spiroaminoborate ester 1 with different borane sources to afford non-racemic alcohols in up to 99% ee. In addition, modest enantioselectivity, aroun...

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Bibliographic Details
Main Authors: Stepanenko, Viatcheslav, De Jesús, Melvin, Correa, Wildeliz, Bermúdez, Lorianne, Vázquez, Cindybeth, Guzmán, Irisbel, Ortiz-Marciales, Margarita
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808030/
https://ncbi.nlm.nih.gov/pubmed/20161579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetasy.2009.11.009
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