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Phosphoinositide 3-Kinase p110β Regulates Integrin α(IIb)β(3) Avidity and the Cellular Transmission of Contractile Forces

Phosphoinositide (PI) 3-kinase (PI3K) signaling processes play an important role in regulating the adhesive function of integrin α(IIb)β(3), necessary for platelet spreading and sustained platelet aggregation. PI3K inhibitors are effective at reducing platelet aggregation and thrombus formation in v...

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Detalhes bibliográficos
Main Authors: Schoenwaelder, Simone M., Ono, Akiko, Nesbitt, Warwick S., Lim, Joanna, Jarman, Kate, Jackson, Shaun P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807342/
https://ncbi.nlm.nih.gov/pubmed/19940148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029132
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