Nuclear Isoforms of Fibroblast Growth Factor 2 Are Novel Inducers of Hypophosphatemia via Modulation of FGF23 and KLOTHO

FGF2 transgenic mice were developed in which type I collagen regulatory sequences drive the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW). The phenotype of TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and decreased serum phosphate (P(i)). Whe...

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Autors principals: Xiao, Liping, Naganawa, Takahiro, Lorenzo, Joseph, Carpenter, Thomas O., Coffin, J. Douglas, Hurley, Marja M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807337/
https://ncbi.nlm.nih.gov/pubmed/19933269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030577
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