Nuclear Isoforms of Fibroblast Growth Factor 2 Are Novel Inducers of Hypophosphatemia via Modulation of FGF23 and KLOTHO

FGF2 transgenic mice were developed in which type I collagen regulatory sequences drive the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW). The phenotype of TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and decreased serum phosphate (P(i)). Whe...

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Detalhes bibliográficos
Main Authors: Xiao, Liping, Naganawa, Takahiro, Lorenzo, Joseph, Carpenter, Thomas O., Coffin, J. Douglas, Hurley, Marja M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807337/
https://ncbi.nlm.nih.gov/pubmed/19933269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030577
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