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Nuclear Isoforms of Fibroblast Growth Factor 2 Are Novel Inducers of Hypophosphatemia via Modulation of FGF23 and KLOTHO

FGF2 transgenic mice were developed in which type I collagen regulatory sequences drive the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW). The phenotype of TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and decreased serum phosphate (P(i)). Whe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xiao, Liping, Naganawa, Takahiro, Lorenzo, Joseph, Carpenter, Thomas O., Coffin, J. Douglas, Hurley, Marja M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807337/
https://ncbi.nlm.nih.gov/pubmed/19933269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030577
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