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The Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7A
We report the solution NMR structures of the N-domain of the Menkes protein (ATP7A) in the ATP-free and ATP-bound forms. The structures consist of a twisted antiparallel six-stranded β-sheet flanked by two pairs of α-helices. A protein loop of 50 amino acids located between β3 and β4 is disordered a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2807310/ https://ncbi.nlm.nih.gov/pubmed/19917612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054262 |
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