An NMR Study of the Interaction of the N-terminal Cytoplasmic Tail of the Wilson Disease Protein with Copper(I)-HAH1

ATP7B is a human P(1B)-type ATPase that has a crucial role in maintaining copper(I) homeostasis. Mutations in the corresponding gene are the cause of Wilson disease. Among its various distinguishing features is a long (∼630 amino acids) N-terminal cytosolic tail containing six domains that are indiv...

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Bibliografiske detaljer
Main Authors: Banci, Lucia, Bertini, Ivano, Cantini, Francesca, Massagni, Chiara, Migliardi, Manuele, Rosato, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666587/
https://ncbi.nlm.nih.gov/pubmed/19181666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805981200
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