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The Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7A

We report the solution NMR structures of the N-domain of the Menkes protein (ATP7A) in the ATP-free and ATP-bound forms. The structures consist of a twisted antiparallel six-stranded β-sheet flanked by two pairs of α-helices. A protein loop of 50 amino acids located between β3 and β4 is disordered a...

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Main Authors: Banci, Lucia, Bertini, Ivano, Cantini, Francesca, Inagaki, Sayaka, Migliardi, Manuele, Rosato, Antonio
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807310/
https://ncbi.nlm.nih.gov/pubmed/19917612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054262
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