Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone: ROLE OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ COACTIVATOR (PGC-1α)

PDK4 (pyruvate dehydrogenase kinase 4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). PDC catalyzes the conversion of pyruvate to acetyl-CoA and is an important control point in glucose and pyruvate metabolism. PDK4 gene expressio...

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Bibliografiske detaljer
Main Authors: Attia, Ramy R., Connnaughton, Sara, Boone, Lindsey R., Wang, Fang, Elam, Marshall B., Ness, Gene C., Cook, George A., Park, Edwards A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Transcription, Chromatin, and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807296/
https://ncbi.nlm.nih.gov/pubmed/19948729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039081
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