Clinically Relevant Infusion Rates of μ-Opioid Agonist Remifentanil Cause Bradypnea in Decerebrate Dogs but not Via Direct Effects in the pre-Bötzinger Complex Region

Systemic administration of μ-opioids at clinical doses for analgesia typically slows respiratory rate. Mu-opioid receptors (MORs) on pre-Bötzinger Complex (pre-BötC) respiratory neurons, the putative kernel of respiratory rhythmogenesis, are potential targets. The purpose of this study was to determ...

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Bibliografiset tiedot
Päätekijät: Mustapic, Sanda, Radocaj, Tomislav, Sanchez, Antonio, Dogas, Zoran, Stucke, Astrid G., Hopp, Francis A., Stuth, Eckehard A. E., Zuperku, Edward J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2010
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807229/
https://ncbi.nlm.nih.gov/pubmed/19906886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00188.2009
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